A supplement of ketones may be the magic bullet that allows patients using weight-loss drugs to avoid the potentially adverse side-effect of a shrinking heart and skeletal muscle, according to a University of Alberta study that fine-tunes the popular therapy to protect lean muscle while shedding the same amount of fat.
“Our original study was prompted by reports showing that people taking semaglutide โ the active ingredient in weight-loss drugs such as Ozempic, Wegovy and Rybelsus โ lost a significant amount of skeletal muscle mass,” says Jason Dyck, a pediatrics professor in the Faculty of Medicine & Dentistry. “We wanted to reproduce that in animal models so that we could find ways to intervene and prevent this from happening.”
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